See the various ways that NSAIDs may further compromise renal function in kidneys with existing dysfunction.
NSAID inhibition of COX-1 can result in reduced renal profusion in some patients, and its inhibition of COX-2 can affect tubular sodium and water handling.1
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Reference: 1. DeMaria AN, Weir MR. Coxibs—beyond the GI tract: Renal and cardiovascular issues. J Pain Symptom Manage. 2003;25(2S):S41-S49.